In addition, plasma concentrations of norepinephrine (NE) were determined in unrestrained animals at 3 h intervals over 24 h. Data were collected every 5 min for 24 h under control conditions and during and after music. Music (Mozart, Symphony # 40 Ligeti, String Quartet # 2) were played for 2 h at 75 dB in the animal cabin starting at the onset of L or D in a cross-over design. Rats were synchronized to a 12 h light (L): 12 h dark (D) regimen in an isolated, ventilated, light-controlled, sound-isolated animal container. Radiotelemetry was used to monitor systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), and motor activity (MA) in male normotensive WKY and hypertensive SHR animals. Radiotelemetry now allows one to monitor cardiovascular functions in freely-moving unrestrained experimental animals. There is continuing discussion on the effect of music ("Mozart effect") on numerous functions in man and experimental animals.
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